Tag Archives: Metabolic

Ambient Air Pollution and Type 2 Diabetes: Do the Metabolic Effects of Air Pollution Start Early in Life?

Diabetes Journal current issue





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VEGF-A-Expressing Adipose Tissue Shows Rapid Beiging and Enhanced Survival After Transplantation and Confers IL-4-Independent Metabolic Improvements

Adipocyte-derived vascular endothelial growth factor-A (VEGF-A) plays a crucial role in angiogenesis and contributes to adipocyte function and systemic metabolism, such as insulin resistance, chronic inflammation, and beiging of subcutaneous adipose tissue. Using a doxycycline-inducible adipocyte-specific VEGF-A–overexpressing mouse model, we investigated the dynamics of local VEGF-A effects on tissue beiging of adipose tissue transplants. VEGF-A overexpression in adipocytes triggers angiogenesis. We also observed a rapid appearance of beige fat cells in subcutaneous white adipose tissue as early as 2 days postinduction of VEGF-A. In contrast to conventional cold-induced beiging, VEGF-A–induced beiging is independent of interleukin-4. We subjected metabolically healthy VEGF-A–overexpressing adipose tissue to autologous transplantation. Transfer of subcutaneous adipose tissues taken from VEGF-A–overexpressing mice into diet-induced obese mice resulted in systemic metabolic benefits, associated with improved survival of adipocytes and a concomitant reduced inflammatory response. These effects of VEGF-A are tissue autonomous, inducing white adipose tissue beiging and angiogenesis within the transplanted tissue. Our findings indicate that manipulation of adipocyte functions with a bona fide angiogenic factor, such as VEGF-A, significantly improves the survival and volume retention of fat grafts and can convey metabolically favorable properties on the recipient on the basis of beiging.

Diabetes Journal current issue





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Adiponectin Deficiency Impairs Maternal Metabolic Adaptation to Pregnancy in Mice

Hypoadiponectinemia has been widely observed in patients with gestational diabetes mellitus (GDM). To investigate the causal role of hypoadiponectinemia in GDM, adiponectin gene knockout (Adipoq–/–) and wild-type (WT) mice were crossed to produce pregnant mouse models with or without adiponectin deficiency. Adenoviral vector–mediated in vivo transduction was used to reconstitute adiponectin during late pregnancy. Results showed that Adipoq–/– dams developed glucose intolerance and hyperlipidemia in late pregnancy. Increased fetal body weight was detected in Adipoq–/– dams. Adiponectin reconstitution abolished these metabolic defects in Adipoq–/– dams. Hepatic glucose and triglyceride production rates of Adipoq–/– dams were significantly higher than those of WT dams. Robustly enhanced lipolysis was found in gonadal fat of Adipoq–/– dams. Interestingly, similar levels of insulin-induced glucose disposal and insulin signaling in metabolically active tissues in Adipoq–/– and WT dams indicated that maternal adiponectin deficiency does not reduce insulin sensitivity. However, remarkably decreased serum insulin concentrations were observed in Adipoq–/– dams. Furthermore, β-cell mass, but not glucose-stimulated insulin release, in Adipoq–/– dams was significantly reduced compared with WT dams. Together, these results demonstrate that adiponectin plays an important role in controlling maternal metabolic adaptation to pregnancy.

Diabetes Journal current issue





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Metabolic Surgery in the Treatment Algorithm for Type 2 Diabetes: A Joint Statement by International Diabetes Organizations

Francesco Rubino
Jun 1, 2016; 39:861-877
Metabolic Surgery and the Changing Landscape for Diabetes Care
: Most-Read Full-Text Articles





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Circulating MicroRNAs to Predict the Risk for Metabolic Diseases in the General Population?

Diabetes Journal current issue





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A Mathematical Model for the Determination of Total Area Under Glucose Tolerance and Other Metabolic Curves

Mary M Tai
Feb 1, 1994; 17:152-154
Short Report
Diabetes Care: Most-Read Full-Text Articles





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Hyperpolarized 13C Magnetic Resonance Treatment Response Monitoring: A New Paradigm for Multiorgan Metabolic Assessment of Pharmacological Interventions?

Diabetes Journal current issue





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Eulogy for the Metabolic Clinical Investigator?

Diabetes Journal current issue





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Clinical Outcomes of Metabolic Surgery: Microvascular and Macrovascular Complications

Ted D. Adams, David E. Arterburn, David M. Nathan, Robert H. Eckel
Jun 1, 2016; 39:912-923
Metabolic Surgery and the Changing Landscape for Diabetes Care
Diabetes Care: Most-Read Full-Text Articles





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Clinical Outcomes of Metabolic Surgery: Efficacy of Glycemic Control, Weight Loss, and Remission of Diabetes

Philip R. Schauer, Geltrude Mingrone, Sayeed Ikramuddin, Bruce Wolfe
Jun 1, 2016; 39:902-911
Metabolic Surgery and the Changing Landscape for Diabetes Care
Diabetes Care: Most-Read Full-Text Articles





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