Tag Archives: Kidney

Use of Canagliflozin in Kidney Transplant Recipients for the Treatment of Type 2 Diabetes: A Case Series

Harindra Rajasekeran
Jul 1, 2017; 40:e75-e76
e-Letters: Observations
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SGLT2 Inhibitors and the Diabetic Kidney

Paola Fioretto
Aug 1, 2016; 39:S165-S171
III. SGLT2 Therapy
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Proximal Tubulopathy: Prime Mover and Key Therapeutic Target in Diabetic Kidney Disease

The current view of diabetic kidney disease, based on meticulously acquired ultrastructural morphometry and the utility of measuring plasma creatinine and urinary albumin, has been almost entirely focused on the glomerulus. While clearly of great importance, changes in the glomerulus are not the major determinant of renal prognosis in diabetes and may not be the primary event in the development of diabetic kidney disease either. Indeed, advances in biomarker discovery and a greater appreciation of tubulointerstitial histopathology and the role of tubular hypoxia in the pathogenesis of chronic kidney disease have given us pause to reconsider the current “glomerulocentric” paradigm and focus attention on the proximal tubule that by virtue of the high energy requirements and reliance on aerobic metabolism render it particularly susceptible to the derangements of the diabetic state. Such findings raise important issues for therapeutic advances specifically targeting the pathophysiological perturbations that develop in this part of the nephron.

Diabetes Journal current issue





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Back to the Future: Glomerular Hyperfiltration and the Diabetic Kidney

Diabetes Journal current issue





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SGLT2 Inhibitors and the Diabetic Kidney

Paola Fioretto, Alberto Zambon, Marco Rossato, Luca Busetto, Roberto Vettor
Aug 1, 2016; 39:165-171
III. SGLT2 Therapy
Diabetes Care: Most-Read Full-Text Articles





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Long-term Benefits of Intensive Glucose Control for Preventing End-Stage Kidney Disease: ADVANCE-ON

Muh Geot Wong, Vlado Perkovic, John Chalmers, Mark Woodward, Qiang Li, Mark E. Cooper, Pavel Hamet, Stephen Harrap, Simon Heller, Stephen MacMahon, Giuseppe Mancia, Michel Marre, David Matthews, Bruce Neal, Neil Poulter, Anthony Rodgers, Bryan Williams, Sophia Zoungas, for the ADVANCE-ON Collaborative Group
May 1, 2016; 39:694-700
Cardiovascular Disease and Diabetes
Diabetes Care: Most-Read Full-Text Articles





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The Hypothalamic Melanocortin Pathway and the Regulation of Glucose Handling in the Kidney: A Sympathetic Look at Brain-Kidney Connection

Diabetes Journal current issue





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