Tag Archives: American

Hepatic but Not Extrahepatic Insulin Clearance Is Lower in African American Than in European American Women

African Americans (AAs) tend to have higher plasma insulin concentrations than European Americans (EAs); the increased insulin concentrations have been attributed to increased secretion and/or decreased insulin clearance by liver or other tissues. This work characterizes the contributions of hepatic versus extrahepatic insulin degradation related to ethnic differences between AAs and EAs. By using a recently developed mathematical model that uses insulin and C-peptide measurements from the insulin-modified, frequently sampled intravenous glucose tolerance test (FSIGT), we estimated hepatic versus extrahepatic insulin clearance in 29 EA and 18 AA healthy women. During the first 20 min of the FSIGT, plasma insulin was approximately twice as high in AAs as in EAs. In contrast, insulin was similar in AAs and EAs after the 20–25 min intravenous insulin infusion. Hepatic insulin first-pass extraction was two-thirds lower in AAs versus EAs in the overnight-fasted state. In contrast, extrahepatic insulin clearance was not lower in AAs than in EAs. The difference in insulin degradation between AAs and EAs can be attributed totally to liver clearance. The mechanism underlying reduced insulin degradation in AAs remains to be clarified, as does the relative importance of reduced liver clearance to increased risk for type 2 diabetes.

Diabetes Journal current issue





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Response to Comment on American Diabetes Association. Standards of Medical Care in Diabetes–2017. Diabetes Care 2017;40(Suppl. 1):S1-S135

William H. Herman
Jul 1, 2017; 40:e94-e95
e-Letters: Comments and Responses
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Comment on American Diabetes Association. Standards of Medical Care in Diabetes–2017. Diabetes Care 2017;40(Suppl. 1):S1-S135

David P. Sonne
Jul 1, 2017; 40:e92-e93
e-Letters: Comments and Responses
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Psychosocial Care for People With Diabetes: A Position Statement of the American Diabetes Association

Deborah Young-Hyman
Dec 1, 2016; 39:2126-2140
Psychosocial Research and Care in Diabetes
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Psychosocial Care for People With Diabetes: A Position Statement of the American Diabetes Association

Deborah Young-Hyman, Mary de Groot, Felicia Hill-Briggs, Jeffrey S. Gonzalez, Korey Hood, Mark Peyrot
Dec 1, 2016; 39:2126-2140
Psychosocial Research and Care in Diabetes
Diabetes Care: Most-Read Full-Text Articles





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Insulin Pump Risks and Benefits: A Clinical Appraisal of Pump Safety Standards, Adverse Event Reporting, and Research Needs: A Joint Statement of the European Association for the Study of Diabetes and the American Diabetes Association Diabetes Technology Working Group

Lutz Heinemann, G. Alexander Fleming, John R. Petrie, Reinhard W. Holl, Richard M. Bergenstal, Anne L. Peters
Apr 1, 2015; 38:716-722
Scientific Statement
Diabetes Care: Most-Read Full-Text Articles





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Hypoglycemia and Diabetes: A Report of a Workgroup of the American Diabetes Association and The Endocrine Society

Elizabeth R. Seaquist, John Anderson, Belinda Childs, Philip Cryer, Samuel Dagogo-Jack, Lisa Fish, Simon R. Heller, Henry Rodriguez, James Rosenzweig, Robert Vigersky
May 1, 2013; 36:1384-1395
Scientific Statement
Diabetes Care: Most-Read Full-Text Articles





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Update on Prevention of Cardiovascular Disease in Adults With Type 2 Diabetes Mellitus in Light of Recent Evidence: A Scientific Statement From the American Heart Association and the American Diabetes Association

Caroline S. Fox, Sherita Hill Golden, Cheryl Anderson, George A. Bray, Lora E. Burke, Ian H. de Boer, Prakash Deedwania, Robert H. Eckel, Abby G. Ershow, Judith Fradkin, Silvio E. Inzucchi, Mikhail Kosiborod, Robert G. Nelson, Mahesh J. Patel, Michael Pignone, Laurie Quinn, Philip R. Schauer, Elizabeth Selvin, Dorothea K. Vafiadis, on behalf of the American Heart Association Diabetes Committee of the Council on Lifestyle and Cardiometabolic Health, Council on Clinical Cardiology, Council on Cardiovascular and Stroke Nursing, Council on Cardiovascular Surgery and Anesthesia, Council
Sep 1, 2015; 38:1777-1803
Scientific Statement
Diabetes Care: Most-Read Full-Text Articles





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Staging Presymptomatic Type 1 Diabetes: A Scientific Statement of JDRF, the Endocrine Society, and the American Diabetes Association

Richard A. Insel, Jessica L. Dunne, Mark A. Atkinson, Jane L. Chiang, Dana Dabelea, Peter A. Gottlieb, Carla J. Greenbaum, Kevan C. Herold, Jeffrey P. Krischer, Ake Lernmark, Robert E. Ratner, Marian J. Rewers, Desmond A. Schatz, Jay S. Skyler, Jay M. Sosenko, Anette-G. Ziegler
Oct 1, 2015; 38:1964-1974
Scientific Statement
Diabetes Care: Most-Read Full-Text Articles





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